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Compulsory vaccination against hepatitis B


Since 1981, there has been a vaccination against Hepatitis B virus. The first vaccines were made from human blood acid. His application was worrying and was withdrawn. In 1986-89, the first recombinant vaccine was introduced.

The gene for infected, identified responsible antigen (HBsAg), identified in 1970, has been artificially propagated into the genome (yeast) of a yeast bacterium (Saccharomyces cerevisiae). Large amounts of recombinant HBsAg produced have been extracted from the yeast bacterium, which is the basis of vaccination. After purification, the vaccine is prepared. The acceleration of the immunological reaction contains aluminum salt and phenoxyethanol for retention.
In Hungary, compulsory age-related protection is provided to students in Grade 8 of the elementary school. Of the various vaccine practices available, the two vaccine regimens (0 times after 6 months) are used for vaccines with a higher antigen content. This vaccination scheme is possible between the ages of 11 and 15 years. For HBV antigen-positive newborns and other age groups, a series of 3 vaccines is used (0 times - 1 month - 6 months). If one (adult) has a faster immune response to the goal (travel, scheduled surgery, organ transplantation), there is also an accelerated vaccine schedule (0 times - 1 day - 1 month or 0 times - 7 days - 21 days). In the case of an accelerated vaccine, an additional vaccine should be administered 1 year after the primary vaccination. Otherwise, a booster vaccination is not required. This also applies to children who have been vaccinated against HBV (with 3 primary vaccinations) before the age of 14 years following compulsory vaccination.

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In addition to the usual vaccination reaction (local swelling, redness, pain), the immunological reaction giving the vaccine symptom can often be observed. This can give rise to anxiety after vaccination with the appearance of oviposition (fraud, punctate bleeding). After the reaction that is suspected to be allergic to yeast, the vaccine consultation can be cleared and the vaccination sequence can be continued. The vaccine does not contain thiomersal (preservative), so thiomersal allergy detected by skin test is not a contraindication. (It should be noted that in the case of thiomersal sensitization, mercury in vaccines would not represent a vaccine contraindication! Thiomersal allergy is manifested in the form of contact allergy, eczema, itchy ulcer, not in the skin)